Several years ago, research scholars noticed a solid link between the incidences of developing cancer and geographical location in which people contracting cancer resided. Residents of higher latitudes like Northern USA reported occurrences of higher rates of death from developing cancer as compared to the residents of the equatorial regions.
A possible explanation for such condition might stem from the fact that at the equatorial regions, the sun’s UVB rays are stronger as compared to the radiations at higher latitudes. Exposure to ultraviolet light from sunlight leads to the production of vitamin D, researchers hypothesized that variation in vitamin D levels might account for this association.
Many scientific hypotheses have come up revolving around the topic of relationship between Vitamin D and various diseases. This can provide a definitive topic for start in further research required in the concerned field.
Dozens of studies have come up with studies that exhibited an association between lower levels of Vitamin d with cancer. Yet, such findings do not necessarily prove that taking vitamin D supplements will lower cancer risk. More vital research needs to be done in this week to establish a solid relation between Vitamin D and Cancer development.
More research is coming up the way, for standardized results.
Considering the rates of Vitamin D deficiency in the North-American population and potential cancer fighting efficiencies of appropriate levels of Vitamin D, many scholars have suggested for a widespread supplementation of Vitamin D levels to overcome the deficiencies.
Studies were carried out in mice, wherein tumours and cancer cells were considered. Dose of Vitamin D in such mice were injected which showed several activities that helped to slow or prevent the further development of cancer, including promoting cellular differentiation, stimulating cell death (apoptosis), and reducing tumour blood vessel formation (angiogenesis).
To fully know the effects of vitamin D on how it works on cancer cells and other health outcomes, novel randomized trials are required to be conducted. However, how much of vitamin D should be used in such trials is still not established. Other important aspects that can be taken into consideration are when to start taking vitamin D, and for how long, to potentially see a benefit.
To arrive at a strong conclusion, researchers are conducting two phase-I trials to determine what dose of vitamin D may be useful. In addition, larger randomized trials have been initiated to examine the potential role of vitamin D in the prevention of cancer.
One Vitamin D/Calcium Polyp Prevention Study was conducted where approximately 2,200 participants were tested with vitamin D supplements given alone or with calcium and it was observed that the development of colorectal adenomas (precancerous growths) in patients was prevented.
Researchers are also studying Vitamin D analogs–chemicals with structures similar to that of vitamin D–which may have the anticancer activity of vitamin D but not its ability to increase calcium levels.
VITAMIN D deficiency is known principally for its association with fractures and bone disease, but, its newly recognized association with risk of several types of cancer is receiving considerable attention.
The high dominance of vitamin D deficiency, combined with the discovery of increased risks of certain types of cancer in those who are deficient, suggest that vitamin D deficiency may prove to be responsible in some way or the other, may contribute up to some extent for causing several thousand premature deaths from various types of cancer like colon, breast, ovarian, and prostate cancer on an annual basis. This discovery created a new impulse for confirming adequate vitamin D intake in order to reduce the risk of cancer.
Vitamin D plays a crucial role in preventing various diseases. Certain evidences from various research studies have exhibited that vitamin D plays a chief role in maintaining good health conditions. Our body constitutes of about 30,000 genes and Vitamin D affects close to 3000 of them which work as Vitamin D receptors in the body of an individual.
As per as a research study that was conducted on a large scale, appropriate levels of Vitamin D can bring down your risk of contracting Cancer as much as 60 percent. Maintaining definite levels of Vitamin D in the body can help prevent at least 16 different types of cancer. This includes pancreatic, lung, ovarian, prostrate and skin cancer.
A strikingly important study was conducted and completed by Joan Lappe and Robert Heaney in 2007, wherein a group of menopausal women were given enough vitamin D to raise their serum levels to 40 ng/ml.
It was observed that such women experienced a striking 77% reduction in the incidences of occurrence in development of cancer. An extraordinary thing is, 40 ng/ml is a relatively modest level.
The latest information proposes that the serum level for vitamin D is 50 to 70 ng/ml. To have such spectacular conclusions at just 40 ng/ml underscores just how powerful and important vitamin D is to your body’s optimal functioning.
However, additional and definite research based on stronger study designs is required to determine whether higher vitamin D levels are related to lower cancer incidence or death rates.